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Dosages of less than 5 mg prednisolone per day are not significant and no steroid cover is requiredwhen the patient has severe osteopenia or is a breast cancer survivor with normal bone mineral density. See the table below to help you decide whether 4 tablets/day is more than adequate when the patient is taking prednisone. CARDIOVASCULAR DEVELOPMENT DRIBECLABS INK MEDICINE. Cardiovascular Disease Pregnenolone has been prescribed to treat vasoconstriction due to coronary artery disease. The risk of serious cardiovascular problems is usually less than 5% if an individual who has coronary artery disease and is receiving prednisone on a frequent basis. However, use of a combination of progestin and estrogen has been recommended, which is shown in studies to prevent hypertension and heart rhythm irregularities in patients with a history of coronary artery disease (58-120). Although a total daily dose of prednisone must be met with oral contraceptives, the use of progestin-only treatment (either single cycle pills or an estrogen pill) does not significantly increase the risk of birth defects other than congenital anomalies in women who are taking daily oral contraceptives. The risk of miscarriage increases with the use of combined oral contraceptives (including transdermal patches and the vaginal ring) with a combined daily dose of progestin-only treatment; this increased risk is likely due to the effects of the medications known generically as ethinyl estradiol and progestin. See the cardiology section for additional information. Cancer and Reproductive Health Pregnenolone has been prescribed for a period of time to women with breast cancer and women who have undergone a hysterectomy with or without hysterectomy or radiation therapy to remove breast cancer in order to reduce the risk of cancer recurrence in a subsequent breast cancer or women with ovarian cancer undergoing chemotherapy (61, 62). Pregnenolone has not been shown to increase the incidence of uterine fibroids in postmenopausal women (63), which might result in increased risk of uterine cancer during or after treatment with hormonal contraceptives (64). However, the risk of malignant uterine tumors has been reported in women using prednisone with a combined daily dose of progestin and estrogen of 3 mg or more. The risk of an abnormal uterine ultrasound in women who receive a combined hormonal contraceptive (such as an oral contraceptive and a progestin vaginal ring) increased more than twice the risk of a spontaneous abortion (65). Similar articles: